Depo-Estradiol Estradiol Cypionate

Brand Name Manufacturers
Depo-Estradiol by Pharmacia/Upjohn
Generic Manufacturers
Depogen by Hyrex
Dep-gynogen by Forest
Estro-cyp by Keene
Goldline
Moore
Rugby
Steris
Pharmacology
Ester with estradiol same effect as endogenous estrogen
Delivery
Sustained release intramuscular injection,
Availability
Approved by U.S. FDA
Indications
Estrogen replacement therapy in females
Contraindications
Active blood clotting disorders. Estrogen-dependent tumors. History of blood clotting disorders associated with estrogen use. History of sensitivity to estradiol or any part of the preparation. Known or suspected breast cancer except in appropriately selected patients.
Adverse reactions
CNS
Convulsions. Dizziness. Headache. Migraine. Mental depression. Spasms of limb and facial muscles.
Eyes
Intolerance to contact lenses. Steepening of corneal curvature.
Gastrointestinal
Abdominal cramps. Bloating. Cholestatic jaundice. Nausea. Vomiting.
Skin
Blotchy skin pigmentation. Localized skin irritation. Loss of scalp hair. Increase of body hair. Red skin patches from capillary congestion.
Other
Blood clotting disorders. Elevated blood pressure. Fluid retention. Glucose intolerance. Increased serum calcium level. Increased sensitivity to light. Liver tumors.