Reginald DE HAMPDEN born abt. 1257 married Nichola DE GRENVILLE.

They had the following children:

Son, John DE HAMPDEN born abt. 1300 in Hampton, Bucks, England.   He married Jane or Joanne DE AYLESBURY in 1329.  John DE HAMPDEN died in 1375.

Daughter, Joanne DE HAMPDEN born abt. 1302 in Hampton, Bucks, England.   She married Edmund MOLINS.

Son, Edmund DE HAMPDEN born abt. 1304 in Hampton, Bucks, England.

Son, Robert DE HAMPDEN born abt. 1306 in Hampton, Bucks, England.   He died in 1346.

Son, Richard DE HAMPDEN born abt. 1308 in Hampton, Bucks, England.   He married Avice or Alice UPTON.

Daughter, Isabel DE HAMPDEN born abt. 1310 in Hampton, Bucks, England.   She married (Sir) Gerard DE BRAYBROKE.

Son, Thomas DE HAMPDEN born abt. 1312 in Hampton, Bucks, England.