ERS mtDNA FTDNA FGS 26 Jan 2015 rev 20 Jun 2015, compiled by Art Staples

GENEALOGICAL BACKGROUND:
Mitochondrial DNA (mtDNA) is passed down from mother to daughter. The mtDNA is also passed from the mother to her sons but the sons cannot pass it on to their children.

1) Marie CHIPAUD b. 26 Nov 1873 in Vicq S/Nahon, d, 02 Jun 1950, in Issoudun, Indre, buried in Guilly, Indre, France, m. Laurian "Louis" DELAIGUE (His 2nd marriage), b abt 1863, d 18 Jan 1945 in Guilly, Indre, France. Children, two daughters and five sons.

2) Georgette DELAIGUE, b. 28 Oct 1909 in Guilly, Indre, d. 15 Sept 1999 in Issoudun, Indre, France, m. 09 Nov 1929, Raymond Alfred JUSSERAND, b. 24 Dec 1905 in Giroux, Indre, d. 01 Feb 1999 in Issoudun, Indre, France. Children, five daughters and one son.

As of January 2015, the mtDNA of Georgette (DELAIGUE) JUSSERAND has been passed to twenty females and twelve male descendents; all but one of the thirty-two recipients of her mtDNA is alive. Of the thirty-two descendants that carry the mtDNA of Georgette, thirty were born in France and two were born in the USA.      

GENETIC STUDY (mtDNA):
Evelyne Raymonde (JUSSERAND) STAPLES, daughter of Georgette tested positive for mtDNA Haplogroup (Hg) T2c-T146C, according to the Family Tree DNA (FTDNA) Full Genome Sequence (FGS) test.

QUESTION: Based on analysis of the FGS test, the furthest down-stream mutation marker number found in the FTDNA test is 16438A. What is the correct Haplogroup (Hg) name?

a) Family tree DNA (FTDNA) (2015) names the haplogroup mutation 146C as Hg T2c-T146C!

b) PyloTree.org; van Oven M, Kayser M. 2009. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30(2):E386-E394. http://www.phylotree.org. doi:10.1002/humu.20921 build 16 (rev. 19 Feb 2014) has the mutation 16438A named as Hg T2c1f. 

1) FTDNA RSRS Results: Taken from the - T2 mtDNA Project - mtDNA Test Results for Members, T2c-T146!

2) FTDNA CRS Results:

3) mthap 16 June 2015 by James Lick (in-part)

mthap version 0.19a (2013-04-08); haplogroup data version PhyloTree Build 16 (2014-02-19)
raw data source EveFastaword.fasta (16KB) http://dna.jameslick.com/mthap/mthap.cgi

FASTA format was uploaded. Based on the markers found, assuming the following regions were completely sequenced: HVR1 (16001~16569) HVR2 (1~574) CR (575~16000). Found 16569 markers at 16569 positions covering 100.0% of mtDNA.

Markers found (shown as differences to rCRS):

HVR2: 73G 146C 263G (309.1C) (315.1C) (523-) (524-)
CR: 709A 750G 1438G 1888A 2706G 4216C 4769G 4917G 6261A 7028T 8697A 8860G 9165C 10463C 10822T 11251G 11719A 11812G 13368A 14233G 14766T 14905A 15326G 15452A 15607G 15928A
HVR1: 16093Y 16126C 16292T 16294T 16296T 16438A (16519C)

Best mtDNA Haplogroup Match:

T2c1f
Defining Markers for haplogroup T2c1f:

HVR2: 73G 146C 263G
CR: 709A 750G 1438G 1888A 2706G 4216C 4769G 4917G 6261A 7028T 8697A 8860G 10463C 10822T 11251G 11719A 11812G 13368A 14233G 14766T 14905A 15326G 15452A 15607G 15928A
HVR1: 16126C 16292T 16294T (16296T) 16438A

Marker path from rCRS to haplogroup T2c1f (plus extra markers):

H2a2a1(rCRS) ⇨ 263G ⇨ H2a2a ⇨ 8860G 15326G ⇨ H2a2 ⇨ 750G ⇨ H2a ⇨ 4769G ⇨ H2 ⇨ 1438G ⇨ H ⇨ 2706G 7028T ⇨ HV ⇨ 14766T ⇨ R0 ⇨ 73G 11719A ⇨ R ⇨ 4216C ⇨ R2'JT ⇨ 11251G 15452A 16126C ⇨ JT ⇨ 709A 1888A 4917G 8697A 10463C 13368A 14905A 15607G 15928A 16294T ⇨ T ⇨ 11812G 14233G (16296T) ⇨ T2 ⇨ 10822T ⇨ T2c ⇨ 6261A 16292T ⇨ T2c1 ⇨ 146C ⇨ T2c1(T146C) ⇨ 16438A ⇨ T2c1f ⇨ (309.1C) (315.1C) (523-) (524-) 9165C 16093Y (16519C)

Good Match! Your results also had extra markers for this haplogroup:
Matches(33): 73G 146C 263G 709A 750G 1438G 1888A 2706G 4216C 4769G 4917G 6261A 7028T 8697A 8860G 10463C 10822T 11251G 11719A 11812G 13368A 14233G 14766T 14905A 15326G 15452A 15607G 15928A 16126C 16292T 16294T (16296T) 16438A
Extras(2): (309.1C) (315.1C) (523-) (524-) 9165C 16093Y (16519C)

CONCLUSION:

The mthap version 0.19a (2013-04-08) and phylo-tree build 16 (2014-02-19) both give the correct haplogroup name for mtDNA marker number 16438a as T2c1f (Age pre-suname era).



TRACKING the ANCESTRAL LINEAGE of HAPLOGROUP T:

The following information is taken from the book "Deep Ancestry, inside the Genographic Project (2006) " by Dr. Spencer Wells, Director of the National Geographic Society, Genographic Project. (In-part) 

Haplogroups (Hg) L1/L0> L2:
Hg L1 coexisted with L0 which likely originated in East Africa around 100,000 years ago. Both L1 & L0 only recently made their way out of Africa. L2 individuals arose about 70,000 years ago from a single female ancestor and first emerged in Western and West Central Africa, They have the most widespread mtDNA in Africa.

Hg L3:
The most common ancestor of Hg L3 is a woman who lived around 80,000 years ago. They are the first modern humans to have left Africa. Descendants of these people currently make up about 10 percent of the Middle Eastern population.

Hg N:
Hg N descended from L3 and also left the African continent as the second wave of modern human migration, across the Sinai Peninsula.

Because almost all the mtDNA lineages found in the Near East and Europe descends from Hg N it is considered a Western Eurasian haplogroup.

Hg R:
The R Clan descends from a woman in Western Eurasia Hg N. Some of clan R members moved north across the Caucasus mountains, their lineages being carried into Europe, about 35,000 years ago, for the first time by the Cro-Magnon.

Today descendants of Hg R dominate the European mtDNA genetic landscape to more than 70 percent of the lineages found there.

Hg T:
The T clan descends from a woman who lived about 40,000 years ago. Hg T has a very wide distribution as far east as the Indus Valley and as far south as the Arabian Peninsula. It is also common in eastern and northern Europe. Although this haplogroup was present during the early and middle Upper Paleolithic, Hg T is considered one of the main genetic signatures of the Neolithic expansions.
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Hg T2, estimated age about 20,000 years ago.

Hg T2c, estimated age about 18,000 years ago.  

Hg T2c1, estimated age about 5,000 years ago.

Hg T2c1f, estimated age is pre-surname for common people. 




RESOURCES:

1) European Haplogroup T (mtDNA), including subclades T2> T2c> T2c1> T2c1f
 http://www.eupedia.com/europe/Haplogroup_T_mtDNA.shtml

2) All European Haplogroups Y-DNA & mtDNA, http://www.eupedia.com/europe/origins_haplogroups_europe.shtml

3) Genetic Genealogy Books, http://www.isogg.org/wiki/Genetic_genealogy_books  

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