Isaac was born at Virginia on 10 November 1828. He was the son of JonathanMiller and RebeccaRinker. He married ElizabethFoltz on 14 December 1854. He married RosannahFoltz on 16 June 1857. Isaac died on 27 April 1907 at age 78. In Isaac's obituary it stated that he had 10 children, which were not named, and that he raised the following children in addition to his own: Thomas Rinker; Lucy Evy; H.D. Funkhouser; Cordelia Miller and Paul Miller..