I.  Marmaduke Semmes (1635 - 1693) born in Charles Co., MD, died in St. Mary's, MD
            mar. (Jul 1668) Fortune (1647 - 1701) born in England, died in Charles Co., MD [Documents]

• James Semmes
• Anthony Semmes (c. 1669 - aft. 15 Aug 1708) born in St. Mary's, MD, died in Charles Co., MD
• Marmaduke Semmes (1675 - c. 15 Jul 1717) born in Charles Co., MD, died in Newport, Charles Co., MD
• John Semmes (c. 1673 - 1724/25) born in St. George, St. Mary's, MD, died in Charles Co., MD

• Marmaduke Semmes
• Ignatius Semmes (c. 1705 - 1740) born in Chandlers Town, Charles Co., MD, died in Charles Co., MD
• Mary Semmes (b. c. 1707) born in Chandlers Town, Charles Co., MD
• Anne Semmes (b. c. 1709) born in Chandlers Town, Charles Co., MD
• Juliana Semmes (b. c. 1711 - bef. 2 Feb 1735) born in Chandlers Town, Charles Co., MD
• [!] James Semmes
• Susannah Semmes (b. c. 1715) born in Chandlers Town, Charles Co., MD
• Joseph Milburn Semmes (1694 - 1764) born in Chandlers Town, Charles Co., MD, prob. died in Charles Co., MD
• Susanna Semmes (b. c. 1696) prob. born in Prince George Co., MD

• Mary Anne Semmes (c. 1740 - c. 1774) born & died in Port Tobacco, Charles Co., MD
• Thomas Semmes (1733/44 - bef. 25 May 1832) born in Port Tobacco, Charles Co., MD, died in Wilkes, GA
• Violetta Letitia Semmes (c. 1736 - 1774) born in Port Tobacco, Charles Co., MD
• Edward Semmes
• Marmaduke Semmes (c. 1734 - bef. 14 Sep 1806) born in Port Tobacco, Charles Co., MD, died in Charles Co., MD
• Martha Semmes (b. c. 1738) born in Port Tobacco, Charles Co., MD
• Susannah Semmes (b. c. 1742) born in Port Tobacco, Charles Co., MD

• Elizabeth Semmes (b. c. 1776) born in MD
• Mary Hawkins Semmes (1780 - 1823) born in MD
• George Semmes (c. 1782 - 14 Apr 1846) born in MD
• Thomas Semmes

• Anna Sophia Semmes (1 Aug 1815 - 1889) born in Alexandria, VA
• Thomas Middleton Semmes (11 Nov 1812 - aft. 3 Sep 1841) born & died in Alexandria, VA
• Mary Elizabeth Semmes
• Douglas Ramsey Semmes (9 May 1822 - 1885) born in Alexandria, VA
• Sarah Wilhelmina Semmes (b. 4 May 1830) born in Alexandria, VA
• William Hawley Semmes (b. 1817) born in Alexandria, VA