Year Geographic Area Disease
1657 Boston Measles
1687 Boston Measles
1690 New York Yellow Fever
1713 Boston Measles
1729 Boston Measles
1732-1733 Worldwide Influenza
1738 South Carolina Small Pox
1739-1740 Boston Measles
1747 Connecticut, Pennsylvania, New York & South Carolina Measles
1759 North America (areas inhabited by whites) Influenza
1761 North America & West Indies Influenza
1772 North America Measles
1775 North America (especially New England) unknown epidemic
1775-1776 Worldwide Influenza (one of the worst outbreaks ever)
1788 Philadelphia & New York Measles
1793 Vermont Influenza & "putrid fever"
1793 Virginia Influenza (killed 500 people in 5 counties in 4 weeks)
1793 Philadelphia Yellow Fever (one of the worst outbreaks ever)
1793 Dover, Delaware "extremely fatal" bilious disorder
1793 Pennsylvania - Harrisburg & Middletown many unexplained deaths
1794 Philadelphia Yellow Fever
1796-1797 Philadelphia Yellow Fever
1798 Philadelphia Yellow Fever (one of the worst outbreaks ever)
1803 New York Yellow Fever
1820-1823 Nationwide - (starts on Schuylkill River, PA & spreads) "fever"
1831-1832 Nationwide - (brought by English emigrants) Asiatic Cholera
1832 New York & other major cities Cholera
1837 Philadelphia Typhus
1841 Nationwide - especially severe in the south Yellow Fever
1847 New Orleans Yellow Fever
1847-1848 Worldwide Influenza
1848-1849 North America Cholera
1850 Nationwide Yellow Fever
1850-1851 North America Influenza
1852 Nationwide - New Orleans, 8,000 die in summer Yellow Fever
1855 Nationwide Yellow Fever
1857-1859 Worldwide Influenza (one of disease's greatest epidemics)
1860-1861 Pennsylvania Small Pox
1865-1873 Philadelphia, New York, Boston, New Orleans, Baltimore, Memphis & Washington, DC A series of recurring epidemics of Smallpox, Cholera, Typhus, Typhoid, Scarlet fever & Yellow fever
1873-1875 North America & Europe Influenza
1878 New Orleans Yellow fever (last great epidemic of disease)
1885 Plymouth, Pennsylvania Typhoid
1886 Jacksonville, FL Yellow Fever
1918 Worldwide Influenza (high point year). More people hospitalized in World War I for
Influenza than wounds. US Army training camps became death camps, with 80% death
rate in some camps.