Many people with the same surname enlisted. At least some of them were family members, including these:
- (probably) David Agnew (H) and his son Johnson Agnew (A)
- Alexander Baird (E) and his brother David Baird (E)
- (probably) Abraham Bancker (F&S) and his son Meriners Bancker (C)
- Jacob Bender(G) and John W Bender (G) may be brothers
- George Black (H) and his son George Black (H)
- Charles E Bournonville and his brother Augustus
- William Burket (B) and his brothers James and Melvin (who both died) [in other regiments]
- Cyrus Cartledge (E) and James Cartledge (E), brothers
- Jeremiah Derr (F) and his brother Aaron Derr (F)
- John Q Dyke (H) and his sons Edwin H Dyke (H) and William H H Dyke (H)
- Augustus Eckhart (C) and his son Charles Eckhart (C) (not certain)
- Amos Godfrey and his brother Stephen Godfrey; their sister Phillipine, married William Knapp
- Edgar Gregory (F&S) and his sons Francis Gregory (A) and Justus Gregory (B)
- Samuel Griffith (E) and his son John Griffith (E)
- John N Hawks alias James Clark (D) and his brother Samuel Hawks (D)
- William Hoover/Hooven (C) and (probably) his son William Hooven/Hoover
- Adam Imler and his brother William Imler, and their cousin Martin Imler
- William H Johnson (K) and his brothers Thomas Johnson (72nd PA) and David Johnson (K 72nd PA)
- George Keever (E) and John Keever (E), brothers
- John Lentz and David Lentz (father and son; this is speculative, based only on tentative identifications of them in the 1860 census)
- Richard McCarter (D) and two brothers, one serving in the 71st PA, and another in the 213th PA (enlisted when 15)
- Adam Murphy (I) and his brother George Murphy (I); possibly also Daniel Murphy (F/D)
- John Partenheimer (B) and his nephew Harold Partenheimer (B)
- Abraham Russell (D) and his brother Isaac Russell (D)
- Joseph Sinex (F&S) and his apparent nephew Robert Sinex Sr (D)
- Jeremiah Small (F) and Jerome Small (F), brothers
- David Stiefel alias David Sterle (H) and his brother Godfried Sterle (H)
- Thomas Stineman (B) and John Stineman (B), brothers
- John Stotsenberg (E) and his brother Jeremiah (I)
- George Rodearmel (D) and George Whistler (K), brothers-in-law
- Abraham Weigle, William Weigle and Benjamin Franklin Weigle, brothers
- Amos Yeatts (F), Charles Yeatts (G), and Howard Yeatts (G) were probably brothers
- George Eyre (F&S) and his brother Benjamin Eyre (A/I)
- William McCoy and John McCoy may be brothers
- George S Phillips and his brother-in-law Samuel Amey
- William Wispert (H) and his sons Adam Wispert (H) and James Wispert (H)
- Charles Smith (B)'s father Leopold Smith served from 3 June 1861 to 27 September 1862 in A 4 Pa Res