He married Rebecca (?)
. He married Martha Gaston Rosborough
was born at York Co., South Carolina
, in 1802. He was census 1850 - free in 1850; The 1850 South Carolina, York Co. lists the following family:
James S. Hemphill, age 48, born in York Co., South Carolina;
Rebecca Hemphill, age 41, born in Union Co., South Carolina;
Nancy M. Cresley, age 14, born in York Co., South Carolina;
John S. Plaxeco, age 70, born in Chester Co., South Carolina.
Not sure if this is the right James Hemphill, but it could be. Rebecca might be his first wife, Nancy might be Rebecca's child from a previous marriage and John Plaxeco could be Rebecca's father.